Merck Millipore is a Life Science leader providing cutting-edge technologies, tools and services for bioscience research and biopharmaceutical manufacturing.
Merck Millipore has expanded its capabilities through strategic acquisitions, targeted capital investments, and organic growth. Today we offer an extensive portfolio of products and services in: Life Sciences, Drug Discovery and Development, Lab Filtration, Lab Water, Upstream Bioprocessing, Downstream Bioprocessing and Process Monitoring.
Assurance of quality
Our European and US service labs have been providing services for over 25 years with a long histiry of collaboration with the World’s biggets Drug Discovery organisations and academic cemtres of excellence. Our biomarker labs are frequently auditted by FDA and EMA for compliance with cGMP / GLP
The ability to profile and screen biologicals and small molecules is increasingly moving to cell-based systems. Such functional assays reveal more deeply the responses of cells to stimuli while increasing understanding of modes of action of targets and their ligands. Our services are built on platforms using this approach, such as
- Automated and manual patch clamp electrophysiology (Ion Channels, >50 targets)
- Calcium flux assays, GTPγS, cAMP (GPCRs, >150 targets)
- Quanititative Cell Imaging using fluorescent / bioluminescent bioassays (Kinase, cell signalling, neurobiology)
- Biochemical profiling of kinases (>299 targets)
- Functional safety & liability profiling (125 tragets)
Our services are bespoke and flexible, accommodating projects of wide-ranging sizes and scopes. We also provide expert advice aimed at finding you the most cost effective and efficient strategies to deliver robust and relibale data for your projects.
From our Oxford (UK) based biomarker testing labs we can advise on and support early and late stage, clinical and non-clinical sample analysis; we validate commercial kits and assess their suitability to diverse regulatory and non-regulatory demands.
We are frequently asked to develop new assays to defined performance criteria making them suitable for data submission to regulatory authorities, and have worked with the following platforms: ELISA, RIA, ECL™, Luminex® technology-based (xMAP), DELFIA®, FACS®, BIAcore and IRMA formats PK/PD and immunogenicity testing on many of the common platforms is also carried out to cGMP / GLP levels if required.
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