Caenorhabditis elegans is an excellent model organism for studying the genetics of development and neurobiology. Its genome is entirely sequenced and the fate of every cell is known throughout development. Also, the complete nervous system connectivity has been determined.
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Our facility for behavioural phenotyping is open for the study of mice and rats. We have access to several models to analyse behaviours in mice and rats, as well as the necessary stereotactic equipment to perform central injections.
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The core facility/platform provides resources and service for physiological characterization of normal and genetically modified mice. A focus is on cardiovascular studies of living conscious animals and on in vitro examination of isolated cardiac and vascular tissue.
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We offer a flexible core facility for high quality and efficient research, aiming at providing the right solution and study set-up for the individual project and to provide modern education to researchers both within and outside Karolinska Institutet.
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Gamma (137 Cs) exposure facilities for high or low dose rate exposures are available for the radiation of e.g cells, cell cultures, DNA and proteins.
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The aim of Karolinska Center for Transgene Technologies (KCTT) is to produce transgenic mice by pronuclear injection and ES cell techniques. KCTT is one of the largest transgenic core facilities in Scandinavia.
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Our state-of-the-art facility, which is the largest in Sweden, houses fish in a continuously monitored environment and all staff are qualified animal technicians. There are already zebrafish models for a number of human diseases, for example cardiomyopathy, diabetes, muscular dystrophy and Parkinson’s disease.
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We can assist studies of gene function in high throughput gene inactivation experiments in cell lines and through the generation transgenic Drosophila melanogaster strains.
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Xenopus laevis oocyte injections may be useful to study various biochemical processes. Scientists requiring this technique may contact me to get help with planning and performing microinjection experiments in Xenopus oocytes. Please note that we provide no service support.
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